![]() ER/PR-positive breast cancer risk is 15% higher in women who first gave birth at an older age, compared with those who did so at a younger age, a meta-analysis showed. The association may be limited to ER/PR-positive tumours. Older age at first giving birthīreast cancer risk increases by 3% for each year older a woman is when she first gives birth, a meta-analysis showed. Some reproductive factors modify sex hormone levels reduction in overall oestrogen exposure may partly explain the link between reproductive factors and breast cancer risk. Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study.
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